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Updated: Feb 17, 2026

An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction
Published on: December 8, 2016
Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology
Pedro M Rodrigues1, Pärt Peterson2, Nuno L Alves1
1Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Thymus Development and Function Laboratory, Instituto de Biologia Molecular e Celular, Porto, Portugal.
Abstract:
Medullary thymic epithelial cells (mTECs) play a central role in T cell tolerance. However, how the mTEC compartment is maintained remains elusive. We review recent discoveries on new transcription factors involved in mTEC homeostasis and discuss the possibility that their actions might be facilitated by the unique biology of mTECs.
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