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Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion
Rubens Fernando Gonçalves Ribeiro1, Rodrigo Paracampo Couteiro2, Andrew Moraes Monteiro2
1Fellow Master degree, Postgraduate Program in Surgery and Experimental Research, Universidade Estadual do Para (UEPA), Brazil. Statistical analysis, manuscript preparation, English language.
Purpose:
To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in liver ischemia/reperfusion injury in rats.
Methods:
25 male rats (Wistar) were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of liver ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during liver ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); Remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments.
Results:
Per+HSS group showed a lower degree of liver dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly improved liver function and reduced histological damage.
Conclusion:
Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute liver injury induced by ischemia/reperfusion.
