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Antioxidants and platelets
1Department of Community Health and General Practice, University of Kuopio, Finland.
Annals of Medicine
|February 1, 1989
Abstract:
It is postulated that antioxidants reduce platelet activity by the stimulation of prostacyclin synthetase by scavenging synthesis-inhibiting peroxides. The experimental and clinical evidence supporting this theory is inconclusive. Clinical trials suggest that vitamin E reduced platelet aggregability. Nonexperimentally, a strong association has been observed between low serum selenium concentration and increased platelet aggregability. These findings suggest that antioxidants have an important role in the regulation of platelet function.