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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
Published on: August 22, 2016
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Adhesive Drug Delivery Systems Based on Polyelectrolyte Complex Nanoparticles (PEC NP) for Bone Healing.
Martin Muller1,2, David Vehlow1,2, Bernhard Torger1,3
1Leibniz-Institut fur Polymerforschung Dresden e.V., Abteilung Polyelektrolyte und Dispersionen, Hohe Straße 6, D-01069 Dresden, Germany.
Current Pharmaceutical Design
|December 15, 2017
Summary
Drug-loaded Polyelectrolyte Complex (PEC) Nanoparticles (NP) offer a stable and cell-compatible coating for Bone Substitute Materials (BSM). These PEC NPs enable sustained drug delivery for bone defect therapy, with potential for on-demand release.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Polyelectrolyte Complex (PEC) Nanoparticles (NP) are explored for functionalizing Bone Substitute Materials (BSM).
- This approach targets bone defects associated with systemic bone diseases.
Purpose of the Study:
- To provide an overview of drug-loaded PEC NP for BSM functionalization.
- To summarize the advantages of using PEC NP in bone defect therapy.
Main Methods:
- PEC NPs fabricated via controlled mixing of polycation and polyanion solutions with charged drugs.
- Characterization using colloid titration, Dynamic Light Scattering (DLS), Scanning Force Microscopy (SFM), FTIR, UV-VIS, and CD spectroscopy.
- Biochemical and microbiological assays were employed.
Main Results:
- PEC NPs exhibit time-dependent colloidal stability for weeks to months.
- Developed PEC NP coatings are cell-compatible with minimal effects on bone-related cells.
- Sustained and delayed elution of drugs (bisphosphonates, antibiotics, growth factors) for bone healing observed.
Conclusions:
- PEC NPs provide a stable, adhesive matrix on BSM, minimizing adverse reactions.
- Drug elution can be triggered (e.g., thermoresponsive polymers) for spatiotemporal control.
- PEC NPs are integrable into existing and novel BSM systems for enhanced bone regeneration.
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