Giant gastrointestinal stromal tumor with predominantly cystic changes: a case report and literature review
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Updated: Feb 17, 2026
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Published on: February 19, 2022
Liying Wang1, Libin Liu2, Zhaohui Liu2
1Department of Gastroenterology, The Second Hospital of Jilin University, No. 218, Ziqiang Street, Changchun, 130042, China. wangly0904@163.com.
Background:
Gastrointestinal stromal tumors (GISTs) rarely present with predominantly cystic changes. Here, we report a case of giant GIST of the stomach with predominantly cystic changes in a 74-year-old female patient.
Case Presentation:
The tumor was 10 cm × 15 cm in size and positive for CD117, H-caldesmon, and DOG-1. Complete surgical resection was performed without regional lymphadenectomy. The patient recovered uneventfully and no recurrence occurred.
Conclusions:
The case illustrates that GIST with cystic changes should be considered in the diagnoses of hepatic and pancreatic lesions. Furthermore, immunohistochemistry with CD117, DOG1, and other molecular markers is critical for diagnosis of GIST of the stomach and facilitates optimization of treatments for GIST.
