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Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9

Lianghai Wang1,2, Xiaodan Yu1,3, Zhiyu Zhang1,4

  • 1Department of Pathology and Key Laboratories for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.

Journal of Experimental & Clinical Cancer Research : CR
|December 15, 2017
PubMed
Abstract

Insights

Novel therapies targeting the linc-ROR/SOX9 network show promise for esophageal squamous cell carcinoma (ESCC). This regulatory axis, involving microRNAs, impacts cancer cell growth and chemoresistance, offering new therapeutic avenues.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Esophageal squamous cell carcinoma (ESCC) requires novel therapies targeting its molecular drivers.
  • The roles of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9) in ESCC are not fully understood.

Purpose of the Study:

  • To investigate the regulatory network between linc-ROR and SOX9 in ESCC.
  • To explore the therapeutic potential of targeting this network in ESCC.

Main Methods:

  • Examined linc-ROR and SOX9 expression in ESCC tissues and cell lines.
  • Assessed the impact of linc-ROR on ESCC cell phenotypes using in vitro assays (CCK8, colony formation, Transwell, sphere formation).
  • Investigated the linc-ROR/SOX9 interaction mechanism involving microRNAs (miRNAs) through bioinformatic analysis, luciferase assays, and RNA-binding protein immunoprecipitation.

Main Results:

  • A positive correlation was observed between linc-ROR and SOX9 expression in ESCC.
  • Silencing linc-ROR inhibited ESCC cell proliferation, motility, chemoresistance, and self-renewal.
  • linc-ROR acts as a sponge for miR-15b, miR-33a, miR-129, miR-145, and miR-206, thereby derepressing SOX9 and promoting malignant phenotypes. linc-ROR depletion reduced tumor growth in vivo.

Conclusions:

  • The linc-ROR-miRNA-SOX9 regulatory network is a potential therapeutic target for ESCC.
  • Targeting this network could offer a novel strategy for improving patient survival in ESCC.
Keywords:
Linc-RORSOX9StemnessTherapy

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