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Pancuronium allergy: a case report.

G Patriarca1, E Nucera, D Schiavino

  • 1Department of Allergology, Catholic University, Rome, Italy.

British Journal of Anaesthesia
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Anesthetist experienced anaphylactic shock to pancuronium bromide, a type I immunological reaction. Prompt treatment led to full recovery, confirmed by extensive allergy testing.

Area of Science:

  • Anesthesiology
  • Immunology
  • Clinical Medicine

Background:

  • Anaphylactic shock is a severe, life-threatening allergic reaction.
  • Pancuronium bromide is a neuromuscular blocking agent commonly used in anesthesia.
  • Identifying the specific allergen is crucial for patient safety and future anesthetic management.

Observation:

  • A 33-year-old male anesthetist collapsed immediately after anesthetic induction.
  • Symptoms included diffuse erythema and probable cardiac arrest.
  • The anesthetic agents administered were fentanyl, droperidol, thiopentone, and pancuronium bromide.

Findings:

  • The patient experienced a type I immunological reaction consistent with anaphylaxis.
  • Comprehensive allergy testing, including skin tests and in vitro assays, identified pancuronium bromide as the causative agent.

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  • Despite the severity of the reaction, the patient recovered fully with prompt medical intervention.

    • Implications:

    • This case highlights the potential for anaphylaxis to pancuronium bromide, even in patients without prior allergy history.
    • It underscores the importance of thorough diagnostic workup to pinpoint specific anesthetic drug allergies.
    • Awareness of this risk can guide anesthetic choices and improve patient safety in susceptible individuals.