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Updated: Feb 17, 2026

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
09:17

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

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Announcement: UEDA Heart Award for 2017

    International Heart Journal
    |December 15, 2017
    PubMed

    Insights

    This announcement highlights four award-winning cardiovascular research articles from 2017. Key studies include generating cardiomyocytes from Duchenne muscular dystrophy patients and the effects of allopurinol on heart failure.

    Area of Science:

    • Cardiovascular Research
    • Regenerative Medicine
    • Heart Failure
    • Pulmonary Hypertension

    Background:

    • The UEDA Heart Awards recognize significant contributions to cardiovascular science.
    • This selection spans diverse areas including stem cell therapy, metabolic interventions, and disease biomarkers.

    Purpose of the Study:

    • To generate induced pluripotent stem cells from Duchenne muscular dystrophy patients and differentiate them into cardiomyocytes.
    • To investigate the effect of allopurinol on myocardial energy metabolism in rats post-myocardial infarction.
    • To evaluate plasma levels of Receptor for Advanced Glycation End-Products (RAGE) and High-Mobility Group Box 1 (HMGB1) in pulmonary hypertension patients.
    • To assess the long-term cost-effectiveness of Tolvaptan in aquaporin-defined responders.

    Main Methods:

    • Generation and differentiation of induced pluripotent stem cells (iPSCs).
    • In vivo studies in rat models of chronic heart failure.
    • Measurement of plasma biomarkers using established assays.
    • Retrospective analysis of medical expenses and length of stay.

    Main Results:

    • Successful generation of cardiomyocytes from Duchenne muscular dystrophy patient-derived iPSCs.
    • Allopurinol demonstrated a positive effect on myocardial energy metabolism in heart failure rats.
    • Elevated levels of RAGE and HMGB1 were observed in pulmonary hypertension patients.
    • Tolvaptan use was associated with reduced long-term medical costs and hospital stays in specific patient groups.

    Conclusions:

    • Induced pluripotent stem cells offer a promising avenue for studying and potentially treating Duchenne muscular dystrophy.
    • Allopurinol may be a potential therapeutic agent for improving cardiac function in heart failure.
    • RAGE and HMGB1 could serve as potential biomarkers for pulmonary hypertension.
    • Tolvaptan demonstrates economic benefits in managing heart failure patients who respond to aquaporin modulation.

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