Comparison between brain natriuretic peptide and calcitonin gene-related peptide in children with dilated cardiomyopathy and controls
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Updated: Feb 17, 2026
Detection and Quantification of Calcitonin Gene-Related Peptide CGRP in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay
Published on: June 16, 2023
Noor Mohammad Noori1, Alireza Teimouri1, Iraj Shahramian2
1Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Insights
In children with dilated cardiomyopathy (DCM), both calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) levels were elevated compared to controls. BNP showed a stronger correlation with disease severity, suggesting it may be a more effective biomarker for DCM in pediatric patients.
Area of Science:
- Pediatric Cardiology
- Biomarker Discovery
- Cardiovascular Research
Background:
- Dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement and impaired systolic function.
- Understanding biomarkers for pediatric DCM is crucial for diagnosis and management.
Purpose of the Study:
- To compare levels of calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) in children with DCM versus healthy controls.
- To evaluate the correlation of CGRP and BNP with disease severity in pediatric DCM.
Main Methods:
- Biomarker levels (BNP, CGRP) were measured using ELISA in pediatric DCM patients and controls.
- Echocardiographic findings were assessed and compared between groups.
- Correlation between biomarker levels and the Ross classification of disease severity was analyzed.
Main Results:
- Children with DCM exhibited significantly higher mean levels of both BNP and CGRP compared to controls (P < 0.001 for BNP, P = 0.001 for CGRP).
- Echocardiographic parameters differed significantly between DCM patients and controls (P < 0.05).
- BNP levels demonstrated a significant positive correlation with the Ross classification of disease severity (P < 0.05), while CGRP did not.
Conclusions:
- Elevated BNP and CGRP levels are observed in children with DCM.
- BNP appears to be a more reliable biomarker for assessing disease severity in pediatric DCM than CGRP.
- BNP may serve as a valuable clinical tool for managing pediatric DCM.
Background:
Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction.
Objective:
This study was performed to determine the level of calcitonin gene-related peptide (CGRP) and brain natriuretic peptide (BNP) in children with DCM and controls and comparison of these two biomarkers in patients.
Materials And Methods:
This study was performed from April 2014 to March 2015 on patients with DCM. The levels of BNP and CGRP were measured by ELISA, and final amounts of biomarkers were compared with the echocardiographic finding.
Results:
In this study, the mean age was 10.567 ± 5.50 and 12.135 ± 4.626 years for controls and cases, respectively (P = 0.321). The majority of echocardiographic indices in the left and right heart had different means in cases and controls (P < 0.05). Means of BNP were 213.814 ± 309.601 and 2.76 ± 1.013 for case and control, respectively (P < 0.001). Means of CGRP were 2.278 ± 1.586 and 1.488 ± 0.501 for cases and controls, respectively, (P = 0.001). In the patients group, however, no significant relationship was observed between CGRP level and Ross classification but observed a direct relationship of Ross classification with BNP (χ2 = 15.845, P < 0.05).
Conclusions:
The present research was performed on DCM patients and showed that most echocardiographic parameters, mean of CGRP and mean of BNP increased in patients compared to healthy children. The severity of illness based on the Ross classification showed significant and positive correlation with BNP level but not with CGRP. Probably, it could be concluded that BNP would be a better biomarker in DCM patients.
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