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Salmonella typhimurium Meningitis in an Infant Presenting with Recurrent Meningitis
Rajendra Prasad Anne1, Pankaj C Vaidya1, Pallab Ray2
1Department of Pediatrics, Advanced Pediatric Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Abstract:
Salmonella typhimurium meningitis in infancy is very uncommon and does not respond to usual duration of empirical antibiotic therapy. A 5-mo-old infant presented with clinical picture of acute pyogenic meningitis and was treated with empirical antibiotic therapy for 14 d. But, 2 wk after the discharge, the child presented again with similar complaints. CSF culture had grown Salmonella typhimurium following which dual antibiotic therapy was given for 6 wk.
Insights
Salmonella typhimurium meningitis is rare in infants and often resists standard antibiotic treatment. This case highlights the need for prolonged, dual therapy for successful infant meningitis recovery.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Salmonella typhimurium meningitis is an infrequent pediatric infection.
- Infantile meningitis typically requires prompt antibiotic intervention.
Observation:
- A 5-month-old infant presented with symptoms suggestive of acute pyogenic meningitis.
- Initial 14-day empirical antibiotic therapy did not resolve the infection.
Findings:
- The infant relapsed with similar symptoms two weeks post-discharge.
- Cerebrospinal fluid (CSF) culture confirmed Salmonella typhimurium.
- A 6-week course of dual antibiotic therapy was administered.
Implications:
- Standard empirical antibiotic durations may be insufficient for Salmonella typhimurium meningitis.
- Prolonged and combination antibiotic strategies are crucial for treating resistant infant meningitis.
- Early identification and appropriate treatment are vital for improving outcomes in infant Salmonella infections.
