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What's new in pituitary pathology?
Sylvia L Asa1,2, Ozgur Mete1,2
1Department of Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
Histopathology
|December 15, 2017
Summary
Advances in pituitary pathology include updated terminology, reclassification of tumors, and new insights into rare lesions and inflammatory conditions. Further research is needed to fully understand the development of these pituitary disorders.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Pituitary disorders significantly impact quality of life and longevity.
- Understanding pituitary pathology is crucial for patient management.
- Recent studies show progress in identifying, classifying, and managing pituitary lesions.
Purpose of the Study:
- To review significant advances in pituitary pathology.
- To highlight key developments in classification, pathogenesis, and management.
- To identify remaining challenges in understanding pituitary disorders.
Main Methods:
- Review of recent significant studies in pituitary pathology.
- Analysis of changes in terminology and classification systems.
- Examination of new pathogenetic mechanisms and rare lesions.
Main Results:
- Terminology shift from 'adenoma' to 'pituitary neuroendocrine tumour'.
- Reclassification of hormone-negative tumors based on transcription factor expression.
- Clarification of hypophysitis, inflammatory pseudotumors, and pituicytoma variants.
- Distinction between papillary and adamantinomatous craniopharyngioma pathogenesis.
Conclusions:
- Significant progress has been made in understanding pituitary pathology.
- Key advances include updated classifications and insights into pathogenesis.
- Further research is required to elucidate the underlying mechanisms of many pituitary disorders.
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