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Maternal alcohol consumption during pregnancy and its association with offspring renal function at 30 years:

Sumon K Das1,2, Harold D McIntyre3,4, Rosa Alati1

  • 1Institute for Social Science Research, School of Social Science, The University of Queensland, Brisbane, Queensland, Australia.

Nephrology (Carlton, Vic.)
|December 15, 2017
PubMed

Insights

Maternal alcohol consumption during pregnancy increases the risk of chronic kidney disease (CKD) in offspring by age 30. This risk is notably higher for female offspring, particularly when alcohol exposure occurs in late pregnancy.

Area of Science:

  • Obstetrics and Gynecology
  • Nephrology
  • Developmental Pediatrics

Background:

  • Prenatal alcohol exposure is a known cause of fetal developmental abnormalities.
  • Experimental studies suggest alcohol impacts fetal kidney development, but human data is limited.
  • Chronic kidney disease (CKD) affects kidney structure and function, with early life factors potentially influencing later development.

Purpose of the Study:

  • To investigate the association between maternal alcohol consumption during pregnancy and the development of CKD in offspring at 30 years of age.
  • To determine if the timing of alcohol exposure (pre-pregnancy, early, or late pregnancy) influences CKD risk.
  • To explore potential sex-based differences in the association between prenatal alcohol exposure and offspring CKD.

Main Methods:

  • A cohort of 1626 Australian offspring (Mothers and their offspring study - MUSP) was analyzed.
  • Serum creatinine was measured at age 30.
  • CKD was classified into stages 1-5 using the CKD-EPI definition based on estimated glomerular filtration rate (eGFR).

Main Results:

  • Seven percent (n=111) of 30-year-old offspring exhibited mild (stage 2) CKD.
  • Moderate to heavy maternal alcohol consumption in late pregnancy was associated with a 2.10-fold increased odds of CKD.
  • The association was stronger in female offspring, with odds ratios of 2.84 for late and 2.94 for early pregnancy exposure.

Conclusions:

  • Maternal alcohol exposure during early and late pregnancy is linked to mild CKD in offspring at age 30.
  • The association between prenatal alcohol exposure and CKD is more pronounced in female offspring compared to males.
  • These findings highlight the long-term renal health implications of prenatal alcohol exposure.
Abstract

Keywords:
alcoholchronic kidney diseasecohortoffspringpregnancy

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