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Crowdsourced Asparagus Urinary Odor Population Kinetics.

Anuradha Ramamoorthy1, Brian M Sadler2, J G Coen van Hasselt3

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This summary is machine-generated.

Asparagus consumption causes smelly urine, with significant differences between people. The odor effect from eating asparagus lasts about 4.7 hours, and age influences this variability.

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Area of Science:

  • Pharmacokinetics and human metabolism
  • Nutritional science and sensory perception

Background:

  • Asparagus consumption is linked to malodorous urine, a phenomenon with notable interindividual variability (IIV).
  • Understanding the kinetics of this post-consumption effect is crucial for characterizing human metabolic responses.

Purpose of the Study:

  • To characterize the urinary odor kinetics following the consumption of asparagus spears.
  • To investigate the dose-response relationship and factors influencing interindividual variability in odor production.

Main Methods:

  • A study involving randomized consumption of asparagus spears by attendees at two professional society meetings.
  • Utilized a mixed-effects proportional odds model to analyze urinary odor perception data from 87 subjects.
  • Collected self-reported urinary odor perception data post-consumption.

Main Results:

  • The estimated half-life of the asparagus-induced malodorous urine effect was 4.7 hours (RSE = 13.2%).
  • A dose-response relationship was identified with good precision (slope term precision = 24.3%).
  • Subject age was identified as a predictor of interindividual variability in the dose-response slope.

Conclusions:

  • The study successfully characterized the kinetics of asparagus-induced malodorous urine.
  • Age is a significant factor contributing to the variability in the duration and intensity of the odor effect.
  • The study design offers a model for crowdsourcing population pharmacokinetic studies in various settings.