Pharmacogenetic landscape of DPYD variants in south Asian populations by integration of genome-scale data
Judith M Hariprakash1, Shamsudheen K Vellarikkal2, Pavithran Keechilat3
1GN Ramachandran Knowledge Center for Genome Informatics, CSIR Institute of Genomics & Integrative Biology, Mathura Road, Delhi 110025, India.
Aim:
Adverse drug reactions to 5-Fluorouracil(5-FU) is frequent and largely attributable to genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims at understanding the pharmacogenetic landscape of DPYD variants in south Asian populations.
Materials & Methods:
Systematic analysis of population scale genome wide datasets of over 3000 south Asians was performed. Independent evaluation was performed in a small cohort of patients.
Results:
Our analysis revealed significant differences in the the allelic distribution of variants in different ethnicities.
Conclusions:
This is the first and largest genetic map the DPYD variants associated with adverse drug reaction to 5-FU in south Asian population. Our study highlights ethnic differences in allelic frequencies.
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