Dynamic flow imaging using 320-detector row CT and motion coherence analysis in coronary aneurysms associated with
Yamato Shimomiya1, Michinobu Nagao2, Yuzo Yamasaki3
11Department of Clinical Application,Ziosoft Inc.Tokyo,Japan.
Insights
This study introduces dynamic flow imaging with 320-row CT to assess coronary artery blood flow in adults with Kawasaki disease and coronary aneurysms, offering new diagnostic insights.
Area of Science:
- Cardiovascular Imaging
- Medical Diagnostics
- Pediatric Cardiology
Background:
- Kawasaki disease can lead to coronary artery aneurysms.
- Assessing coronary blood flow in these aneurysms is clinically important.
- Current imaging methods may have limitations in dynamic flow assessment.
Purpose of the Study:
- To introduce and evaluate a novel dynamic flow imaging technique using 320-detector row CT.
- To assess coronary blood flow dynamics in adult patients with Kawasaki disease and coronary aneurysms.
- To compare flow parameters between patients and healthy controls.
Main Methods:
- Employed dynamic coronary CT angiography with a 320-row detector CT scanner.
- Acquired data over 15-25 cardiac cycles during mid-diastole with ECG gating.
- Calculated coronary flow index (CFI) using the maximum slope method on time-density curves.
Main Results:
- Measured coronary flow indexes in proximal, distal, and intra-aneurysmal coronary artery segments.
- Quantified dynamic blood flow characteristics in patients with Kawasaki disease-associated aneurysms.
- Established a method for assessing coronary hemodynamics in this patient cohort.
Conclusions:
- Dynamic flow imaging with 320-row CT is a feasible method for assessing coronary blood flow in Kawasaki disease aneurysms.
- This technique provides quantitative insights into altered hemodynamics.
- Further research can validate its clinical utility in managing Kawasaki disease complications.
Abstract:
Introduction We propose a new dynamic flow imaging using 320-detector row CT, and investigate the assessment of coronary flow in aneurysms of Kawasaki disease in adulthood.
Methods:
Six patients with Kawasaki disease and coronary aneurysms associated (26.7 years old) and six controls were enrolled. Dynamic coronary CT angiography with 320-row CT was continuously performed at mid-diastole throughout 15-25 cardiac cycles with prospective Electrocardiogram gating after injection of contrast media. Dynamic data sets of 15-25 cycles were computed into 90-100 data sets by motion coherence image processing. Next, time-density curves for coronary arteries were calculated for all the phases. On the basis of the maximum slope method, coronary flow index was defined as the ratio of the maximum upslope of the attenuation of coronary arteries to the upslope of the attenuation of ascending aorta on the time-density curves. Coronary flow indexes for the proximal and distal sites of coronary arteries and intra-aneurysm were measured.
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