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Related Experiment Videos

Prolactin response to fentanyl in depression.

E Frecska1, M Arato, C M Banki

  • 1National Institute of Nervous and Mental Diseases, Budapest.

Biological Psychiatry
|March 15, 1989
PubMed
Summary

Fentanyl administration significantly impacts prolactin secretion, with higher responses in the evening. Depressed patients showed similar prolactin responses to healthy individuals, but blunted responses were linked to suicide risk.

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Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Pharmacology

Background:

  • Major depression is a complex mood disorder with potential neuroendocrine dysregulation.
  • Opioid agonists like fentanyl can influence pituitary hormone secretion, including prolactin.
  • Understanding prolactin response to opioids may offer insights into depression pathophysiology.

Purpose of the Study:

  • To investigate the prolactin secretory response to fentanyl in unmedicated women with major depression compared to healthy controls.
  • To examine diurnal variations in prolactin response to fentanyl.
  • To explore potential correlations between prolactin response blunting and suicide risk in depressed individuals.

Main Methods:

  • Ten unmedicated female inpatients with major depression (DSM-III) and 10 healthy female volunteers participated.

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  • Intravenous fentanyl (0.1 mg) was administered at 9:00 AM and 9:00 PM on separate days.
  • Serial blood sampling was conducted for 1 hour post-injection to measure prolactin levels.
  • Repeated measures Analysis of Variance was used for statistical analysis.

    • Main Results:

    • Fentanyl administration significantly affected prolactin secretion (p < 0.0001).
    • Evening injections resulted in significantly elevated prolactin responses compared to morning injections (p < 0.005).
    • No significant difference in prolactin response was observed between depressed patients and healthy controls.

    Conclusions:

    • Fentanyl stimulates prolactin secretion, with a pronounced effect in the evening.
    • While overall prolactin response to fentanyl did not differ between groups, blunted responses were noted in some depressed patients.
    • A subset of depressed patients with blunted prolactin response to fentanyl exhibited increased suicide risk within one year, suggesting a potential biomarker.