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Longitudinal vitamin D deficiency is inversely related to mite sensitization in early childhood

Chih-Yung Chiu1,2,3, Kuan-Wen Su1,3,4, Ming-Han Tsai1,3

  • 1Department of Pediatrics, Chang Gung Memorial Hospital at Keelung and Chang Gung University College of Medicine, Taoyuan, Taiwan.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|December 15, 2017
PubMed

Insights

Persistent vitamin D deficiency in early childhood is linked to higher eosinophil and IgE levels, potentially increasing allergy risk. This longitudinal study tracked vitamin D and allergy markers in children up to age five.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Immunology
  • Longitudinal Cohort Studies

Background:

  • Limited research exists on the long-term effects of vitamin D deficiency on childhood atopic diseases.
  • Understanding these associations is crucial for early intervention strategies.

Purpose of the Study:

  • To longitudinally analyze vitamin D levels in children from birth to five years.
  • To investigate the relationship between vitamin D status and the development of atopic diseases and allergy markers.

Main Methods:

  • A birth cohort of 155 children was followed for five years.
  • Vitamin D levels were clustered using K-means analysis.
  • Absolute eosinophil count (AEC) and IgE levels (total and specific to allergens) were measured at multiple time points.

Main Results:

  • Vitamin D levels were stratified into three clusters: sufficient (≥30 ng/mL), intermediate (20-29.9 ng/mL), and deficient (<20 ng/mL).
  • Persistent vitamin D deficiency correlated with eosinophilia at age 3 and elevated total serum and mite-specific IgE at age 4.
  • Mite sensitization at age 4 was linked to an increased risk of allergic rhinitis and asthma.

Conclusions:

  • Vitamin D deficiency shows an inverse association with absolute eosinophil count and mite-specific IgE.
  • These findings suggest that vitamin D deficiency may heighten susceptibility to allergies like rhinitis and asthma in early childhood.
Abstract

Keywords:
allergic sensitizationasthmaeosinophillongitudinal vitamin D deficiency

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