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Chikage Noishiki1, Gen Takagi2, Yoshiaki Kubota2

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Endothelial dysfunction, a condition linked to hypertension, is associated with keloid formation and worsening. Impaired vascular endothelial cell function may play a role in abnormal wound healing and keloid development.

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Area of Science:

  • Dermatology
  • Vascular Biology
  • Wound Healing Research

Background:

  • Keloids are characterized by excessive collagen deposition due to impaired wound healing and persistent inflammation.
  • Hypertension is often associated with more severe keloid scarring.
  • Endothelial dysfunction, a hallmark of hypertension, is investigated for its potential role in keloid pathogenesis.

Purpose of the Study:

  • To assess the association between endothelial dysfunction and the formation and progression of keloids.
  • To investigate if markers of endothelial function correlate with keloid development.

Main Methods:

  • A prospective cross-sectional study involving patients with keloids and nonkeloid controls.
  • Endothelial function was measured using digital reactive hyperemia peripheral arterial tonometry, yielding reactive hyperemia index (RHI) and augmentation index (AI) values.
  • Binomial logistic regression was used to analyze the association between endothelial function markers and keloid development.

Main Results:

  • Patients with keloids exhibited significantly poorer RHI and AI values compared to nonkeloid controls.
  • Poor RHI and AI values were significantly associated with keloid development.
  • Keloid patients whose scars appeared before age 18 or after age 30 showed significantly poorer AI values than controls.

Conclusions:

  • Endothelial dysfunction may contribute to the formation and/or aggravation of keloids.
  • Vascular endothelial cells appear to play a critical role in the complex process of wound healing and scar formation.
  • Targeting endothelial function could be a potential therapeutic strategy for managing keloids.