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A modified microdosimetric kinetic model for relative biological effectiveness calculation.

Yizheng Chen1,2, Junli Li1,2, Chunyan Li1,3

  • 1Department of Engineering Physics, Tsinghua University, Beijing 100084, People's Republic of China.

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A modified microdosimetric kinetic model (MMKM) improves heavy ion therapy by accounting for DNA double-strand break (DSB) yield variations with linear energy transfer (LET). This enhanced model offers more accurate RBE calculations for clinical treatment planning.

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Biophysics

Background:

  • Heavy ion therapy requires accurate Relative Biological Effectiveness (RBE) dose calculations.
  • The microdosimetric kinetic model (MKM) is used for RBE prediction but has theoretical limitations regarding DNA double-strand break (DSB) yield and its dependence on linear energy transfer (LET).
  • Experimental data indicates that DSB yield, a primary lesion, is influenced by particle LET, contradicting the MKM's assumption of radiation quality independence.

Purpose of the Study:

  • To develop a modified microdosimetric kinetic model (MMKM) that incorporates LET-dependent primary lesion yields.
  • To improve the accuracy of RBE calculations in heavy ion therapy by addressing the limitations of the existing MKM.
  • To evaluate the impact of the MMKM on clinical dose distribution and cell survival fraction predictions.

Main Methods:

  • Developed a modified microdosimetric kinetic model (MMKM) by incorporating an RBE_DSB-LET curve based on experimental DSB yields.
  • Simulated spread-out Bragg peaks (SOBP) using Geant4 Monte Carlo code for carbon ion irradiation.
  • Calculated biological and clinical dose distributions and averaged cell survival fractions using both MKM and MMKM.

Main Results:

  • The MMKM accurately reproduces the LET-dependent variation of the α and β parameters, aligning better with experimental data than the MKM.
  • Clinical dose distributions calculated with MMKM show discrepancies within 10% compared to MKM in the SOBP, but MMKM offers more accurate predictions before and after the SOBP.
  • The MKM may overestimate clinical dose at the distal end of the SOBP, while MMKM provides a more precise calculation of cell survival fractions, with discrepancies exceeding 15% at high doses.

Conclusions:

  • The MMKM provides a more accurate representation of RBE for heavy ion therapy by considering LET-dependent primary lesion yields.
  • The MMKM demonstrates improved accuracy in predicting clinical dose distributions and cell survival fractions compared to the conventional MKM.
  • The MMKM offers a valuable tool for enhancing the precision of treatment planning in heavy ion therapy.