Related Experiment Video
Updated: Feb 16, 2026
06:13
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
1.8K
Interindividual Responses of Appetite to Acute Exercise: A Replicated Crossover Study
Fernanda R Goltz1,1, Alice E Thackray1,1, James A King1,1
1National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UNITED KINGDOM.
Medicine and Science in Sports and Exercise
|December 15, 2017
Summary
Acute exercise impacts appetite hormones like ghrelin and peptide YY (PYY), but individual responses vary significantly. This study confirms these individual differences in appetite and hormone changes after exercise.
Area of Science:
- Exercise Physiology
- Endocrinology
- Appetite Regulation
Background:
- Acute exercise influences appetite-regulatory hormones and perceived hunger.
- Individual variability in these responses to exercise is acknowledged but not well-quantified.
- Replicated studies are necessary to robustly assess the reproducibility of exercise-induced appetite changes.
Purpose of the Study:
- To examine the reproducibility of appetite and appetite-regulatory hormone responses to acute exercise.
- To quantify individual differences in perceived appetite and hormone responses following exercise.
- To investigate the consistency of responses across repeated exercise bouts.
Main Methods:
- Fifteen healthy men underwent two control (rest) and two exercise (60-min treadmill running) conditions in a randomized crossover design.
- Measurements included perceived appetite, acylated ghrelin, and total peptide YY (PYY) before and after each condition.
- Interindividual differences were assessed by correlating response variations between exercise and control conditions, with statistical analysis using linear mixed models.
Main Results:
- Exercise significantly suppressed acylated ghrelin and appetite perceptions while elevating total PYY compared to control.
- Greater variability in response changes was observed during exercise compared to control conditions for all measured variables.
- Strong positive correlations indicated reproducibility of individual responses, with significant participant-condition interactions present for appetite and hormone levels.
Conclusions:
- This study quantified individual differences in appetite and hormone responses to acute exercise, demonstrating variability beyond random fluctuations.
- Replicated exercise bouts revealed reproducible, yet distinct, individual patterns in appetite regulation.
- Findings highlight the personalized nature of physiological responses to exercise, impacting appetite control.
Related Concept Videos
01:16Crossover Experiments
4.6K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
4.6K
01:30Regulation of Food Intake
2.9K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.9K
01:20Exercise and Cardiovascular Response
4.6K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
4.6K
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
164
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
164
01:11Bioavailability Study Design: Single Versus Multiple Dose Studies
255
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
255