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Cytokine alterations in panic disorder: A systematic review
Laiana Azevedo Quagliato1, Antonio E Nardi1
1Laboratory of Panic & Respiration, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Journal of Affective Disorders
|December 15, 2017
Summary
Panic disorder (PD) is linked to elevated levels of certain inflammatory markers like IL-6 and IL-1β. Further research into these cytokine profiles may clarify PD
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Panic disorder (PD) affects 3.4-4.7% of the population.
- Inflammatory processes are increasingly implicated in mental disorder pathophysiology.
- Few studies have investigated cytokine levels in PD patients.
Purpose of the Study:
- To systematically review the cytokine profile in PD patients.
- To discuss future research directions for PD.
- To understand the role of inflammation in PD.
Main Methods:
- Comprehensive literature search in PubMed and Web of Science.
- Included studies measuring cytokines in PD patients.
- Keywords included "panic disorder" and specific cytokines (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, TNF-alpha, INF-gamma).
Main Results:
- Eleven studies were included in the review.
- Increased serum levels of IL-6, IL-1β, and IL-5 were reported in PD patients compared to controls.
- Conflicting results exist for IL-2, IL-12, and INF-γ in association with PD.
Conclusions:
- Discrepant findings in PD and cytokine literature exist.
- Heterogeneity may stem from assay variability and differing study populations.
- Investigating inflammatory biomarkers in PD is crucial for understanding its pathophysiology.
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