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Updated: Feb 16, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Contemporary management of high-grade gliomas
Hao-Wen Sim1, Erin R Morgan1, Warren P Mason1
1Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.
Abstract:
High-grade gliomas, including glioblastoma, are the most common malignant brain tumors in adults. Despite intensive efforts to develop new therapies for these diseases, treatment options remain limited and prognosis is poor. Recently, there have been important advances in our understanding of the molecular basis of glioma, leading to refinements in our diagnostic and management approach. There is new evidence to guide the treatment of elderly patients. A multitude of new agents have been investigated, including targeted therapies, immunotherapeutics and tumor-treating fields. This review summarizes the key findings from this research, and presents a perspective on future opportunities to advance the field.
Insights
High-grade gliomas, such as glioblastoma, are aggressive brain tumors with poor prognoses. Recent molecular insights are guiding new diagnostic and therapeutic strategies, including targeted therapies and immunotherapeutics.
Area of Science:
- Neuro-oncology
- Molecular Biology
- Clinical Therapeutics
Background:
- High-grade gliomas (e.g., glioblastoma) represent the most frequent adult malignant brain tumors.
- Current treatment options for these aggressive tumors are limited, with poor patient outcomes.
- Advances in understanding glioma molecular biology are improving diagnostics and management.
Purpose of the Study:
- To review recent therapeutic advancements for high-grade gliomas.
- To highlight new evidence for treating elderly glioma patients.
- To provide a future outlook on novel treatment strategies.
Main Methods:
- Review of recent scientific literature on glioma research.
- Analysis of emerging therapeutic agents and approaches.
- Synthesis of findings to inform future research directions.
Main Results:
- Significant progress in understanding glioma molecular underpinnings.
- Investigation of novel agents including targeted therapies, immunotherapeutics, and tumor-treating fields.
- Emerging evidence specifically addressing the treatment of elderly patients.
Conclusions:
- New molecular insights are refining glioma diagnosis and management.
- Novel therapeutic strategies show promise for improving patient outcomes.
- Future research opportunities exist to further advance glioma treatment.
