Related Experiment Videos
Functional muscarinic supersensitivity in denervated rat hippocampus
D M Benson1, R D Blitzer, V Haroutunian
1Department of Psychiatry and Pharmacology, Mt. Sinai School of Medicine, Bronx, NY.
Brain Research
|January 30, 1989
Abstract:
The effects of carbachol (CCh), a cholinergic agonist, were compared in voltage-clamped hippocampal pyramidal neurons in vitro, obtained from normal and fimbria-fornix-lesioned rats. A substantial increase in sensitivity to the effects of CCh was seen in denervated neurons. The supersensitivity was demonstrated on both the inward leak current and the calcium-dependent potassium current, IAHP. These findings provide convincing evidence for cholinergic denervation supersensitivity in the hippocampus.