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Updated: Feb 16, 2026
Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
Published on: September 19, 2014
Development and characterization of an anthropomorphic breast phantom for permanent breast seed implant brachytherapy
Michael Roumeliotis1, Sarah Quirk1, Matthew Skarsgard2
1Department of Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada; Department of Medical Physics, Tom Baker Cancer Centre, Calgary, Alberta, Canada; Department of Oncology, Tom Baker Cancer Centre, Calgary, Alberta, Canada.
Purpose:
To develop an anthropomorphic breast phantom for use in credentialing of permanent breast seed implant brachytherapy.
Methods And Materials:
A representative external contour and target volume was used as the basis of mold manufacturing for anthropomorphic breast phantom development. Both target and normal tissue were composed of gel-like materials that provide suitable computed tomography and ultrasound contrast for brachytherapy delivery. The phantoms were evaluated for consistency in construction (target location) and Hounsfield unit (computed tomography contrast). For both target and normal tissue, the speed of sound was measured and compared to the image reconstruction algorithm's expectation value. Five phantoms were imaged preimplant and postimplant to assess interphantom similarity as well as to evaluate the uncertainty in quantifying seed position.
Results:
The average Hounsfield units of the target and normal tissue gels is -146 ± 5 and 23 ± 1, respectively. The average speed of sound of the target and normal tissue gels is 1485 ± 7 m/s and 1558 ± 9 m/s, respectively, resulting in an estimated 0.4 mm uncertainty in image guidance. The registration/deformation uncertainty was determined to be 0.8 mm. The standard combined uncertainty in assessing seed position spatial accuracy, also including a 0.9 mm estimate based on literature for seed localization, is estimated to be 1.3 mm.
Conclusions:
The development of the anthropomorphic breast phantom and evaluation of both the consistency as well as overall seed position uncertainty illustrates the suitability of this phantom for use in brachytherapy end-to-end delivery and implant accuracy evaluation. When evaluating a user's implant accuracy, we estimate a standard combined uncertainty of 1.3 mm.
