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Lessons from CKD-Related Genetic Association Studies-Moving Forward
Sophie Limou1,2,3,4, Nicolas Vince1,2, Afshin Parsa5,6
1Centre de Recherche en Transplantation et Immunologie Unité Mixte de Recherche 1064, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Nantes, Nantes, France.
Genetic studies have identified key factors influencing kidney function across various populations, including those with diabetes and chronic kidney disease (CKD). This research advances understanding and paves the way for precision medicine in nephrology.
Area of Science:
- Nephrology
- Genetics
- Genomics
Background:
- Genetic association studies have significantly advanced the understanding of kidney function.
- Numerous determinants of kidney function have been identified in diverse populations, including those with diabetes, hypertension, chronic kidney disease (CKD), end-stage renal disease (ESRD), and glomerulonephritis (GN).
Purpose of the Study:
- To review major discoveries and advances in genetic research related to kidney function.
- To predict future directions for identifying genetic and molecular processes underlying kidney dysfunction.
- To facilitate the transition towards precision medicine in nephrology.
Main Methods:
- Review of genetic association studies.
- Analysis of findings in general, diabetic, hypertensive, CKD, ESRD, and GN populations.
- Synthesis of current knowledge and future predictions.
Main Results:
- Identification of numerous genetic determinants affecting normal and pathological kidney function.
- Novel and unanticipated findings improving understanding of kidney disease pathways.
- Progress in identifying genetic factors across various kidney disease types.
Conclusions:
- Genetic research has yielded significant insights into kidney function and disease.
- Future research should focus on accelerating the identification of genetic/molecular processes for precision medicine.
- This approach aims to define pathophysiological subgroups and therapeutic targets for kidney dysfunction.
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