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Related Concept Videos

RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Updated: Feb 16, 2026

Bacterial Delivery of RNAi Effectors: Transkingdom RNAi
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Bacterial Delivery of RNAi Effectors: Transkingdom RNAi

Published on: August 18, 2010

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RNA interference-based therapy and its delivery systems.

Xiuhui Chen1,2, Lingegowda S Mangala1,3, Cristian Rodriguez-Aguayo3,4

  • 1Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cancer Metastasis Reviews
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PubMed
Summary
This summary is machine-generated.

RNA interference (RNAi) offers targeted gene silencing for diseases like cancer. Developing effective nanocarrier delivery systems is key to overcoming challenges and realizing RNAi

Keywords:
Cancer therapyDelivery systemsNanoparticlesRNA interference

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Nanomedicine

Background:

  • RNA interference (RNAi) is a gene silencing technique with therapeutic potential for diseases including cancer.
  • Clinical application of RNAi is hindered by challenges in systemic delivery of RNA molecules.
  • Effective delivery systems are crucial for overcoming RNAi's instability, delivery barriers, and immune responses.

Purpose of the Study:

  • To review current progress in therapeutic RNAi applications, particularly in cancer therapy.
  • To highlight strategies for optimizing RNAi delivery systems.
  • To discuss the role of nanocarriers in enhancing RNAi efficacy.

Main Methods:

  • Literature review of recent advancements in RNAi therapeutics and delivery systems.
  • Focus on lipid-based nanoparticles as a promising delivery strategy.
  • Analysis of challenges and solutions for systemic RNAi delivery.

Main Results:

  • Significant efforts have been made to develop advanced RNAi delivery systems.
  • Nanocarriers, especially lipid-based nanoparticles, show promise in overcoming delivery obstacles.
  • Targeted delivery strategies are crucial for enhancing therapeutic outcomes.

Conclusions:

  • RNAi holds great promise for treating various diseases, especially cancer.
  • Optimized nanocarrier systems are essential for successful clinical translation of RNAi.
  • Further development of smart delivery systems will unlock the full therapeutic potential of RNAi.