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Mirabegron: potential off target effects and uses beyond the bladder
Nodi Dehvari1, Edilson Dantas da Silva Junior2, Tore Bengtsson1
1Department of Molecular Biosciences, The Wenner-Gren Institute, Arrhenius Laboratories F3, Stockholm University, Stockholm, Sweden.
British Journal of Pharmacology
|December 16, 2017
Summary
Mirabegron, a beta-3 adrenoceptor agonist, shows efficacy in humans for overactive bladder. This review explores its potential off-target effects and broader therapeutic applications beyond bladder control.
Area of Science:
- Molecular Pharmacology
- Drug Discovery
- Metabolic Disease Research
Background:
- Beta-3 adrenoceptor (β3AR) agonists were promising for obesity and diabetes due to rodent studies.
- Previous β3AR drugs failed in clinical trials, likely due to poor human efficacy.
- Mirabegron, a β3AR agonist with demonstrated human efficacy, is approved for overactive bladder.
Purpose of the Study:
- To review the off-target effects of mirabegron.
- To explore potential new therapeutic uses for mirabegron.
- To assess the clinical relevance of mirabegron's off-target actions.
Main Methods:
- Literature review of mirabegron's pharmacology.
- Analysis of clinical trial data for mirabegron.
- Examination of preclinical studies on β3AR and related targets.
Main Results:
- Mirabegron is effective for overactive bladder.
- Evidence suggests mirabegron may interact with additional receptors/targets.
- The clinical significance of these off-target interactions is not fully established.
Conclusions:
- Mirabegron's efficacy extends beyond its primary target.
- Further research is needed to understand mirabegron's off-target profile.
- Mirabegron holds potential for treating conditions like heart failure and metabolic diseases.
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