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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Transient Myocardial Thickening in Cats Associated with Heart Failure

J Novo Matos1,2, N Pereira2, T Glaus2

  • 1Royal Veterinary College, University of London, Hatfield, UK.

Journal of Veterinary Internal Medicine
|December 16, 2017
PubMed

Insights

Transient myocardial thickening (TMT) in cats is associated with a better prognosis than hypertrophic cardiomyopathy (HCM). Cats with TMT experienced resolution of congestive heart failure (CHF) and improved cardiac function, unlike those with persistent HCM.

Area of Science:

  • Veterinary Cardiology
  • Cardiovascular Diseases in Cats

Background:

  • Some cats with hypertrophic cardiomyopathy (HCM) and congestive heart failure (CHF) can experience resolution of both left ventricular hypertrophy and CHF.
  • Transient myocardial thickening (TMT) is a condition where cats present with thickened heart muscle that can resolve.

Purpose of the Study:

  • To characterize cats with TMT and CHF.
  • To compare the clinical features of cats with TMT and CHF to those with persistent HCM and CHF.

Main Methods:

  • A retrospective study analyzed clinical records from four veterinary centers.
  • Cats were categorized into TMT (initial left ventricular wall thickness [LVWT] ≥6 mm, resolving to <5.5 mm with CHF resolution) and HCM (persistent LVWT ≥6 mm) groups.
  • A total of 21 cats with TMT and 21 cats with HCM were included.

Main Results:

  • Cats with TMT were significantly younger (2 years) than those with HCM (8 years).
  • In TMT cats, LVWT normalized, and left atrium/aorta (LA/Ao) ratios decreased, with CHF recurrence in only 1 cat.
  • All TMT cats survived the study period, contrasting with a high mortality rate in HCM cats.

Conclusions:

  • Transient myocardial thickening occurs in younger cats, often following antecedent events.
  • The prognosis for cats with CHF associated with TMT is significantly better than for those with persistent HCM.
Abstract

Keywords:
HCM phenocopyHypertrophic cardiomyopathyMyocarditisTakotsubo cardiomyopathy

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