[Development in synthesis of andrographolide derivatives]
Yu Luo1,2, Qiu Shen3, Bao-Lin Wang1,2
1Nanchang Institute for Food and Drug Control, Nanchang 330038, China.
Summary
Andrographolide, a compound from Andrographis paniculata, and its derivatives exhibit diverse biological activities, including anti-inflammatory and anti-tumor effects. This review covers their synthesis and pharmacological properties.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Andrographolide is a key active compound found in Andrographis paniculata.
- It and its derivatives demonstrate a broad spectrum of biological activities.
Purpose of the Study:
- To review the synthesis of andrographolide derivatives.
- To summarize their associated pharmacological activities.
Main Methods:
- Literature review of synthesis pathways.
- Compilation of reported pharmacological data.
Main Results:
- Andrographolide derivatives possess anti-inflammatory, antiviral, anti-tumor, anti-HIV, and hepatoprotective properties.
- They also show α-glucosidase inhibition activity.
Conclusions:
- Andrographolide derivatives are promising therapeutic agents.
- Further research into their synthesis and applications is warranted.
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