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Updated: Feb 16, 2026

Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
Published on: November 11, 2021
Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma
Leili Saeednejad Zanjani1, Zahra Madjd1,2, Maryam Abolhasani1,3
1Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Aim:
Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes.
Discussion & Conclusion:
Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC.
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