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Clinical Application of Detecting 21-Gene Recurrence Score in Predicating Prognosis and Therapy Response of Patients
Guodong Xiao1, Jinying Meng2, Jing Zhang1
1a Department of Thoracic Surgery and Oncology, the Second Department of Thoracic Surgery , Cancer Center, the First Affiliated Hospital of Xi'an Jiaotong University , Xi'an, Shaanxi Province , China.
Abstract:
To determine the most suitable strategy in treating patients with invasive breast cancer from Northwest China. Lower recurrence score (RS) correlated with lower recurrence ratio. Patients having a medium-high 21-gene RS who received adjuvant therapy presented lower recurrence risk. Younger patients having RS results (⩾31) tended to accept adjuvant therapy more often, however, those having intermediate RS results were inclined to wait and did not receive chemotherapy. These results suggested that RS-based precision medicine will allow individualized diagnosis and treatment, resulting in better outcomes and preserved medical resources.
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