A Case of Chloramphenicol Resistant Primary Syphilis Treated with Penicillin

A primary syphilis patient was treated with oral chloromycetin therapy at a dose of 2 capsules 4 hourly for 16 days ie. total 192 capsules or 48 gms. His original serological titre was VDRL 1:64 and W R 1:160 dil. MKR Positive Kahn + + +, DG,Tp + +.After therapy his titre declined to VDRL 1:8 dil within 11 weeks but then it was at this level for 28 weeks. He had no history of reinfection during follow up period. Then he was given penicillin at a rate of 1lac 4 hourly for 15 days i.e. total 90 lacs. After penicillin therapy within 12weeks his serum was negative of all serological tests done.