Related Experiment Video
Updated: Feb 16, 2026

12:03
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
13.0K
Periosteal Ewing Sarcoma in a 65-Year-Old Man: A Case Report
Julia Bedard1, Jessica Burns1, Amalia de Comas2,3
1Department of Orthopaedics, University of Arizona College of Medicine-Phoenix, Phoenix, Arizona.
JBJS Case Connector
|December 16, 2017
Summary
This case report details the oldest patient diagnosed with periosteal Ewing sarcoma, a rare bone cancer subtype. The 65-year-old man
Area of Science:
- Orthopedic Oncology
- Rare Bone Malignancies
Background:
- Ewing sarcoma typically affects children and adolescents.
- Periosteal Ewing sarcoma is an extremely rare subtype, with fewer than 30 cases documented.
Observation:
- A 65-year-old male presented with a tibial mass.
- Magnetic resonance imaging showed a superficial tibial mass without medullary canal involvement.
Findings:
- Histological examination confirmed periosteal Ewing sarcoma.
- This represents the oldest patient reported with this rare condition.
Implications:
- Highlights the possibility of periosteal Ewing sarcoma in older adults.
- Emphasizes the importance of considering rare diagnoses in atypical presentations.
Related Concept Videos
Bone Disorders
5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.6K
Osteoclasts in Bone Remodeling
4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K
Spongy Bone
8.3K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
8.3K

