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Cooperativity between antibiotics and antiseptics: testing the bactericidal effect.

S Jenull¹, H Laggner², I Hassl³

¹PhD student, Department of Molecular Genetics, MFPL, Medical University of Vienna, Austria.

Journal of Wound Care

|December 16, 2017

Summary

Octenidine, an antiseptic, showed varied effectiveness with antibiotics in wound care. It enhanced bacterial growth inhibition for Bordetella petrii but not Staphylococcus aureus, suggesting specific interactions.

Keywords:

antibiotic antiseptic bacteria beta-isodona chlorhexidine octenidine taurolin

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Area of Science:

Microbiology
Wound Care
Antimicrobial Agents

Background:

Antibiotics and antiseptics are frequently combined in wound infection treatment.
The interaction between these agents can influence overall efficacy.
Octenidine is a commonly used antiseptic with potential for synergistic effects.

Purpose of the Study:

To evaluate the effectiveness of octenidine (Oct) and octenidine+ (Oct+) in wound care.
To investigate the cooperative effects between octenidine and common antibiotics against pathogenic bacteria.
To compare octenidine's efficacy with other classical antiseptics like povidone-iodine, chlorhexidine, and taurolin.

Main Methods:

Agar diffusion tests were performed using Staphylococcus aureus and Bordetella petrii.
The effectiveness of octenidine alone and in combination with antibiotics was assessed.
Comparisons were made against povidone-iodine, chlorhexidine, and taurolin.

Main Results:

Significant interactions between antibiotics and antiseptics were observed, altering bactericidal efficiency.
Octenidine combined with certain antibiotics effectively inhibited Bordetella petrii growth.
This synergistic effect was not observed with Staphylococcus aureus.
Octenidine demonstrated a unique interaction profile, avoiding sequestration issues seen with other antiseptic/antibiotic combinations.

Conclusions:

The combination of antibiotics and antiseptics can lead to enhanced or reduced antimicrobial activity.
Octenidine's interaction with antibiotics is organism-dependent.
These findings offer valuable insights for selecting appropriate antimicrobial agents in wound infection management.