Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ascorbic acid: a factor concentrated in human gastric juice.

B J Rathbone1, A W Johnson, J I Wyatt

  • 1Department of Medicine, St James's University Hospital, Leeds, U.K.

Clinical Science (London, England : 1979)
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multifidus muscle cross-sectional area adaptations over two volleyball seasons and one off-season in athletes with and without low back pain.

Journal of back and musculoskeletal rehabilitation·2022
Same author

Wetland and Stream Buffer Size Requirements-A Review.

Journal of environmental quality·2021
Same author

Comparison of LI-RADS with other non-invasive liver MRI criteria and radiological opinion for diagnosing hepatocellular carcinoma in cirrhotic livers using gadoxetic acid with histopathological explant correlation.

Clinical radiology·2021
Same author

Author Correction: Egyptian metallic inks on textiles from the 15<sup>th</sup> century BCE unravelled by non-invasive techniques and chemometric analysis.

Scientific reports·2019
Same author

Egyptian metallic inks on textiles from the 15<sup>th</sup> century BCE unravelled by non-invasive techniques and chemometric analysis.

Scientific reports·2019
Same author

Influence of Cropping Systems on Stem Rot (Sclerotium rolfsii), Meloidogyne arenaria, and the Nematode Antagonist Pasteuria penetrans in Peanut.

Plant disease·2019

Gastric juice normally contains high levels of ascorbic acid (A + D). Chronic gastritis significantly reduces these levels, with ascorbic acid predominantly in an inactive form in patients with gastritis.

Area of Science:

  • Gastroenterology
  • Nutritional Biochemistry

Background:

  • Ascorbic acid, a vital antioxidant, plays a role in various physiological processes.
  • Gastric juice composition and its relation to mucosal health are areas of ongoing research.

Purpose of the Study:

  • To quantify ascorbic acid levels in gastric juice and tissue.
  • To investigate the impact of chronic gastritis on gastric ascorbic acid concentrations and forms.

Main Methods:

  • Gastric juice and biopsy samples were analyzed for total ascorbic acid (A + D) using the 2,4-dinitrophenylhydrazine method.
  • High-performance liquid chromatography (h.p.l.c.) was employed to differentiate between ascorbic acid (A) and dehydro-ascorbic acid (D).

Main Results:

  • Normal gastric juice exhibited ascorbic acid (A + D) concentrations approximately three times higher than plasma levels.

Related Experiment Videos

  • Patients with chronic gastritis showed significantly reduced gastric juice ascorbic acid (A + D) concentrations, irrespective of gastritis grade.
  • Ascorbic acid (A + D) levels were higher in the gastric antrum compared to the gastric body.
  • In normal gastric histology, ascorbic acid (A) was predominantly in its active form; in gastritis, it was mainly in its oxidized, inactive form.

    • Conclusions:

    • The stomach actively secretes substantial amounts of ascorbic acid (A + D).
    • Chronic gastritis is associated with diminished gastric ascorbic acid levels and a shift towards its inactive, oxidized form.
    • These findings suggest a potential role for ascorbic acid in gastric health and disease.