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Incidence of malignant hyperthermia in patients undergoing general anesthesia: Protocol for a systematic review and
Junyong In1, Eun Jin Ahn, Dong Kyu Lee
1Department of Anesthesiology and Pain Medicine, Dongguk University Ilsan Hospital, Gyeonggido Department of Anesthesiology and Pain Medicine, Inje University Seoul Paik Hospital Department of Anesthesiology and Pain Medicine, Guro Hospital, Korea University School of Medicine Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
Background:
Malignant hyperthermia (MH) continues to be of potential concern for clinicians whenever inhalational anesthetic agents or succinylcholine are used, because MH is a potentially fatal metabolic disorder.
Methods:
A systematic and comprehensive search will be performed using MEDLINE, EMBASE, and Google Scholar, for studies published up to November 2017. Peer-reviewed prospective cohort studies, retrospective cohort studies, and cross-sectional studies or reports issued by government organizations reporting the incidence or prevalence of MH will be eligible for inclusion. The quality of included studies will be assessed using the Newcastle-Ottawa scale and the modified risk of bias tool. Heterogeneity of estimates across studies as well as publication bias will be assessed. This systematic review and meta-analysis will be performed according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guidelines and reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. All statistical analyses will be conducted using the Stata SE version 15.0.
Results:
The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.
Conclusion:
To our knowledge, this systematic review and meta-analysis will be the first to evaluate existing research on the incidence of MH. Our study will provide an overall estimate of the incidence of MH. Subgroup analysis will assess the incidence of MH according to age, gender, geographical region, race, and the provoking agent if possible. The review will benefit patients, healthcare providers, and policymakers.
Ethics And Dissemination:
Ethical approval and informed consent are not required, as the study will be a literature review and will not involve direct contact with patients or alterations to patient care.
Trial Registration Number:
The protocol for this review has been registered in the PROSPERO network (registration number: CRD42017076628).
Insights
Malignant hyperthermia (MH) is a dangerous metabolic disorder. This study provides the first comprehensive estimate of MH incidence, aiding patient care and policy.
Area of Science:
- Anesthesiology
- Pharmacology
- Medical Genetics
Background:
- Malignant hyperthermia (MH) is a potentially fatal metabolic disorder.
- MH is a concern when using inhalational anesthetic agents or succinylcholine.
- This study addresses the need for updated incidence data on MH.
Purpose of the Study:
- To systematically review and meta-analyze the existing literature on the incidence of Malignant hyperthermia (MH).
- To provide an overall estimate of MH incidence.
- To conduct subgroup analyses based on demographic and clinical factors.
Main Methods:
- Comprehensive literature search of MEDLINE, EMBASE, and Google Scholar up to November 2017.
- Inclusion of peer-reviewed prospective cohort, retrospective cohort, and cross-sectional studies.
- Quality assessment using Newcastle-Ottawa scale and risk of bias tool; adherence to MOOSE and PRISMA guidelines.
Main Results:
- The results of this systematic review and meta-analysis will be published in a peer-reviewed journal.
- This study aims to provide an overall estimate of MH incidence.
- Subgroup analyses will explore incidence variations by age, gender, region, race, and agent.
Conclusions:
- This systematic review and meta-analysis will be the first to evaluate research on MH incidence.
- The study will offer a crucial overall estimate of MH incidence.
- Findings will benefit patients, healthcare providers, and policymakers by informing practice and policy.
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