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Serum corin is associated with the risk of chronic heart failure

Zongliang Yu1, Xiang Lu2, Weiting Xu3

  • 1Department of Cardiology, The First People's Hospital of Kunshan Affiliated to Jiangsu University, Kunshan, China.

Oncotarget
|December 17, 2017
PubMed

Insights

Serum corin levels are lower in patients with chronic heart failure (CHF). Lower corin levels are associated with increased risk and severity of both ischemic and non-ischemic heart failure.

Area of Science:

  • Cardiology
  • Biochemistry
  • Protease Function

Background:

  • Corin is a critical protease regulating blood pressure and cardiac function.
  • Understanding factors associated with chronic heart failure (CHF) risk is crucial for cardiovascular health.
  • Previous research highlights corin's role in cardiovascular homeostasis.

Purpose of the Study:

  • To investigate the association between serum corin levels and the risk of chronic heart failure (CHF).
  • To determine if serum corin levels correlate with the incidence of ischemic and non-ischemic heart failure.
  • To explore the relationship between serum corin levels and CHF severity.

Main Methods:

  • A case-control study involving 484 CHF patients and 484 healthy controls.
  • Logistic regression analysis was employed to assess the relationship between serum corin and CHF.
  • Multivariate analysis was used to adjust for potential confounding factors.

Main Results:

  • CHF patients exhibited significantly lower serum corin levels compared to controls.
  • Lower serum corin levels were inversely correlated with the risk of both ischemic and non-ischemic heart failure.
  • Decreased serum corin levels were associated with increased CHF severity.

Conclusions:

  • Serum corin levels are reduced in patients with chronic heart failure.
  • Reduced serum corin is a potential biomarker for increased risk and severity of heart failure.
  • Corin may play a protective role in the pathogenesis of heart failure.

Keywords:
chronic heart failurecorinrisk

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