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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

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Related Experiment Video

Updated: Feb 16, 2026

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

Long non-coding RNAs for osteosarcoma in the mouse: a meta-analysis.

Shaopu Hu^1,2, Junli Chang^1,2, Yimian Li^1,2

¹Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

|December 17, 2017

Summary

Long non-coding RNAs (lncRNAs) show promise as diagnostic biomarkers and therapeutic targets for osteosarcoma in mice. Rescuing abnormal lncRNA expression may inhibit osteosarcoma progression, guiding future clinical trials.

Keywords:

lncRNA meta-analysis mice osteosarcoma

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Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

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Published on: October 28, 2021

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

Osteosarcoma is a primary bone malignancy, a major cause of cancer death in children and adolescents.
Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in regulating gene expression and contributing to cancer development.

Purpose of the Study:

To evaluate the potential of lncRNAs as diagnostic biomarkers for osteosarcoma.
To assess lncRNAs as therapeutic targets for osteosarcoma in preclinical models.
To guide the design of future preclinical experiments and clinical trials for osteosarcoma.

Main Methods:

Systematic literature search across multiple databases (PubMed, Web of Science, Embase, etc.) up to June 20, 2017.
Independent screening and data extraction by two researchers.
Meta-analysis using tumor volume and tumor weight as outcome measures.

Main Results:

lncRNAs were identified as potential diagnostic biomarkers for osteosarcoma.
lncRNAs demonstrated potential as therapeutic targets for osteosarcoma.
Rescuing abnormally expressed lncRNAs was shown to inhibit osteosarcoma progression in mice.

Conclusions:

lncRNAs hold significant potential as diagnostic biomarkers and therapeutic targets for osteosarcoma.
Further rigorous basic research is essential before clinical trials and application in patient care.
This meta-analysis provides a foundation for future investigations into lncRNA-based osteosarcoma therapies.