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Published on: June 16, 2023
Long non-coding RNAs for osteosarcoma in the mouse: a meta-analysis
Shaopu Hu1,2, Junli Chang1,2, Yimian Li1,2
1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Abstract:
Osteosarcoma, one of the most common primary bone malignances, is a leading cause of cancer death among children and adolescents. Recently, growing studies have found that long non-coding RNAs (lncRNAs) can interfere with the expression of various genes, and participate in the occurrence and development of malignancies. The purpose of this study is to evaluate the potential functions of lncRNAs as diagnostic biomarkers and therapeutic targets for osteosarcoma in mice, thus to direct the strict design for the future preclinical experiments and clinical trials. We systematically searched PubMed, Web of Science, Embase, China Knowledge Resource Integrated Database, VIP, Chinese BioMedical and Wan Fang Database from their initiation date to June 20, 2017. Two researchers independently screened the literatures and withdrew the data, which used the tumor volume and tumor weight as the outcome measures. A total of 10 studies were included, and the results of this meta-analysis revealed that lncRNAs could serve as the diagnostic biomarkers and therapeutic targets for osteosarcoma; and progression of osteosarcoma in mice could be inhibited via rescuing the abnormally expressed lncRNAs. It is necessary to carry out more rigorous basic experiments before lncRNAs can be further investigated in the clinical trials and used in future clinical practices.
Insights
Long non-coding RNAs (lncRNAs) show promise as diagnostic biomarkers and therapeutic targets for osteosarcoma in mice. Rescuing abnormal lncRNA expression may inhibit osteosarcoma progression, guiding future clinical trials.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Osteosarcoma is a primary bone malignancy, a major cause of cancer death in children and adolescents.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their role in regulating gene expression and contributing to cancer development.
Purpose of the Study:
- To evaluate the potential of lncRNAs as diagnostic biomarkers for osteosarcoma.
- To assess lncRNAs as therapeutic targets for osteosarcoma in preclinical models.
- To guide the design of future preclinical experiments and clinical trials for osteosarcoma.
Main Methods:
- Systematic literature search across multiple databases (PubMed, Web of Science, Embase, etc.) up to June 20, 2017.
- Independent screening and data extraction by two researchers.
- Meta-analysis using tumor volume and tumor weight as outcome measures.
Main Results:
- lncRNAs were identified as potential diagnostic biomarkers for osteosarcoma.
- lncRNAs demonstrated potential as therapeutic targets for osteosarcoma.
- Rescuing abnormally expressed lncRNAs was shown to inhibit osteosarcoma progression in mice.
Conclusions:
- lncRNAs hold significant potential as diagnostic biomarkers and therapeutic targets for osteosarcoma.
- Further rigorous basic research is essential before clinical trials and application in patient care.
- This meta-analysis provides a foundation for future investigations into lncRNA-based osteosarcoma therapies.
