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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

18
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Cross-reactivity00:42

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Allergic Drug Reactions01:27

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

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Basophil Activation Test for Allergy Diagnosis
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Peanut Allergy: An Epidemiologic Analysis of a Large Database.

Frederick E Leickly1, Kirsten M Kloepfer1, James E Slaven1

  • 1Section of Pediatric Pulmonology, Allergy, and Sleep Medicine, Department of Pediatrics, Indiana University School of Medicine and Riley Hospital for Children, Indiana University Health, Carmel, IN.

The Journal of Pediatrics
|December 17, 2017
PubMed
Summary

This study analyzed 1070 children with peanut allergy, finding most reactions were skin-related. Severe reactions from accidental exposure in sensitized children were rare, offering reassurance for families.

Keywords:
peanut allergypeanut allergy epidemiologypeanut registry

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Area of Science:

  • Pediatric Allergy and Immunology
  • Food Hypersensitivity Research

Background:

  • Peanut allergy is a growing concern for families and healthcare providers.
  • Evolving strategies for peanut allergy prevention and treatment necessitate updated data.

Purpose of the Study:

  • To confirm new observations on peanut allergy.
  • To address current concerns regarding peanut allergy management.

Main Methods:

  • Analysis of a registry of 1070 children with a history of peanut allergy or sensitization over 5 years.
  • Focus on questions posed by a food allergy support group.

Main Results:

  • Two-thirds of children experienced a reaction to peanut.
  • Skin reactions (55%) and anaphylaxis (35%) were common; median reaction age was 1 year.
  • Comorbidities included atopic dermatitis (60%) and asthma (41%); 58% had other food allergies.
  • Second exposures led to more severe reactions in 28%; severe reactions from inadvertent exposure in sensitized children were rare (<1%).

Conclusions:

  • Registry data provides valuable insights into peanut allergy in children.
  • Findings can help families and healthcare providers navigate current challenges in peanut allergy management.