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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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Updated: Feb 16, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Crohn's disease.

María Pilar Ballester Ferré1, Marta Maia Boscá-Watts1, Miguel Mínguez Pérez1

  • 1Servicio de Medicina Digestiva, Hospital Clínico Universitario de Valencia, Valencia, España.

Medicina Clinica
|December 17, 2017
PubMed
Summary
This summary is machine-generated.

Crohn

Keywords:
Crohn's diseaseDiagnostic-therapeutic managementEnfermedad de CrohnEnfermedad inflamatoria intestinalInflammatory bowel diseaseManejo diagnóstico-terapéutico

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Area of Science:

  • Gastroenterology and Immunology

Background:

  • Crohn's disease is a chronic inflammatory bowel disease (IBD) with unknown causes.
  • It involves patchy, transmural lesions throughout the gastrointestinal tract, leading to impaired immune responses.
  • Symptoms like abdominal pain and diarrhea significantly impact patient quality of life.

Purpose of the Study:

  • To highlight the increasing incidence and prevalence of Crohn's disease.
  • To emphasize the impact on clinical practice and the need for updated diagnostic and therapeutic techniques.
  • To stress the importance of physician familiarity with disease management to prevent complications.

Main Methods:

  • This abstract does not detail specific methods but discusses the disease's characteristics and clinical impact.
  • It focuses on the clinical presentation, epidemiology, and management implications of Crohn's disease.

Main Results:

  • Crohn's disease presents with periods of activity and remission.
  • The condition affects the entire GI tract, from mouth to anus.
  • Increasing incidence and prevalence necessitate advanced clinical management.

Conclusions:

  • Primary care physicians and gastroenterologists must be knowledgeable about Crohn's disease management.
  • Early and effective management is crucial for reducing complication risks.
  • Familiarity with diagnostic and therapeutic advancements is essential for optimal patient care.