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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Postocclusional Hyperemia for Fractional Flow Reserve After Percutaneous Coronary Intervention
Yoshiaki Kawase1, Hiroyuki Omori2, Masanori Kawasaki2
1From the Department of Cardiovascular Medicine, Gifu Heart Center, Japan (Y.K., H.O., T.T., T.H., S.O., H.O., J.K., M.O., H.K., T.S., H.M.); Department of Cardiology, Gifu University Graduate School of Medicine, Japan (M.K.); and Department of Biostatistics and Bioinformatics, Graduate School of Medicine, The University of Tokyo, Japan (A.H.). ykawase@heart-center.or.jp.
Background:
Postocclusional hyperemia caused by balloon occlusion is a potential alternative method of inducing hyperemia for measuring post-percutaneous coronary intervention fractional flow reserve (FFR). The aim of this study was to investigate postocclusional hyperemia as a method of inducing hyperemia.
Methods And Results:
FFR measured by postocclusional hyperemia (FFRoccl) caused by balloon occlusion after percutaneous coronary intervention was compared with FFR measured by drug-induced hyperemia (FFR measured by intravenous ATP; and FFR measured by intracoronary papaverine injection [FFRpap]) in 98 lesions from 98 patients. The hyperemia duration was also measured for FFRoccl and FFRpap. The correlation coefficient between FFRoccl, FFR measured by intravenous ATP (r=0.973; P<0.01), and FFRpap (r=0.975; P<0.01) showed almost identical values to those obtained for the correlation coefficient between FFR measured by intravenous ATP and FFRpap (r=0.967; P<0.01). No clear difference was observed on Bland-Altman analysis. Hyperemia duration was significantly longer with FFRoccl than with FFRpap (70±22 versus 51±25 s; P<0.01).
Conclusions:
Strong correlations were found between FFRoccl and FFR measured by intravenous ATP and FFRoccl and FFRpap. Hyperemia caused by FFRoccl was significantly longer than that caused by FFRpap.
