Related Experiment Video
Updated: Feb 16, 2026
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
13.1K
Rothia dentocariosa endophthalmitis following intravitreal injection-a case report.
R A Hayes1,2, H Y Bennett3,4, S O'Hagan4,5
1University of Queensland School of Medicine, Brisbane, Australia. rylan.hayes@health.qld.gov.au.
Journal of Ophthalmic Inflammation and Infection
|December 17, 2017
Summary
This case report details Rothia dentocariosa endophthalmitis after intravitreal injection, highlighting the risk of oral bacterial contamination. Prompt treatment improved vision but revealed retinal necrosis.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- A 57-year-old diabetic female developed endophthalmitis after intravitreal aflibercept injection.
- Symptoms included decreased vision, pain, and redness in the right eye.
Discussion:
- Rothia dentocariosa was identified as the causative agent of endophthalmitis.
- The case highlights the risk of oral bacterial contamination during intravitreal injections.
- A 'pink hypopyon' was observed, a sign previously noted with other organisms.
Key Insights:
- Early diagnosis and treatment with intraocular and systemic antibiotics, along with vitrectomy, led to visual improvement.
- Despite treatment, extensive retinal necrosis was observed nine weeks post-onset.
- Rothia dentocariosa is a rare but significant cause of post-injection endophthalmitis.
Outlook:
- Vigilance and strategies to minimize bacterial contamination during intraocular injections are crucial.
- Further research into preventing oral bacterial contamination, possibly including patient mask use, is recommended.
