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QTc dispersion and Cornell duration product can predict 10-year outcomes in hypertensive patients with left

Dragan B Djordjević1,2, Ivan S Tasić1,2, Svetlana I Kostić2

  • 1Medical Faculty, Department of Internal Medicine, University of Niš, Niš, Serbia.

Clinical Cardiology
|December 17, 2017
PubMed

Insights

In patients with hypertension and left ventricular hypertrophy (LVH), a positive Cornell product and increased QTc dispersion predict worse 10-year outcomes. These non-invasive markers aid in identifying high-risk individuals for improved management.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Clinical Prediction

Background:

  • Persistent and adequate treatment of arterial hypertension is crucial for better patient outcomes.
  • Left ventricular hypertrophy (LVH) is a known complication of hypertension.
  • Additional non-invasive predictors of prognosis in hypertensive patients with LVH require identification.

Purpose of the Study:

  • To identify non-invasive predictors of unfavorable prognosis in patients with essential arterial hypertension and LVH.
  • To evaluate the 10-year outcome in a cohort of hypertensive patients with LVH.
  • To assess the prognostic significance of the Cornell product and QTc dispersion.

Main Methods:

  • A cohort of 124 hypertensive patients with LVH was studied noninvasively.
  • Patients received regular medication therapy throughout the 10-year follow-up period.
  • Baseline parameters including left ventricular mass index, QTc dispersion, Cornell product, and Lyon-Sokolow score were assessed.

Main Results:

  • Unfavorable outcomes occurred in 32.3% of patients over 10 years.
  • Patients with unfavorable outcomes had higher baseline left ventricular mass index and QTc dispersion.
  • A positive Cornell product was more frequent in patients with unfavorable outcomes (35% vs. 22.2%).

Conclusions:

  • The Cornell product and QTc dispersion are significant predictors of unfavorable 10-year outcomes in hypertensive patients with LVH.
  • Elevated QTc dispersion (>65 ms) and a positive Cornell product identify patients at higher risk.
  • These non-invasive parameters can aid in risk stratification and management of hypertensive patients with LVH.
Abstract

Keywords:
Cardiac HypertrophyEchocardiographyElectrocardiographyHypertension

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