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Relationships of kidney injury molecule-1 with renal function and cardiovascular risk factors in the general

Peter Egli1, Stefanie Aeschbacher1, Matthias Bossard2

  • 1Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland; Division of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 17, 2017
PubMed

Insights

Kidney injury molecule-1 (KIM-1) in healthy adults showed no link to kidney function but was associated with cardiovascular risk factors like blood pressure and cholesterol.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker Research

Background:

  • Kidney injury molecule-1 (KIM-1) is linked to kidney damage in patients with existing renal disease.
  • Limited data exists on KIM-1's association with renal function and cardiovascular risk in healthy general populations.

Purpose of the Study:

  • To investigate the relationship between plasma KIM-1 levels and renal function in healthy adults.
  • To assess the association of KIM-1 with cardiovascular risk factors in a general healthy population.

Main Methods:

  • A population-based study included 2060 healthy adults aged 25-41 years.
  • Exclusion criteria included high BMI, pre-existing kidney or cardiovascular disease.
  • Plasma KIM-1 was measured using a high-sensitivity assay; multivariable linear regression analyzed associations.

Main Results:

  • No significant relationship was found between KIM-1 and creatinine or cystatin C.
  • Plasma KIM-1 levels showed significant linear relationships with systolic and diastolic blood pressure.
  • KIM-1 was also associated with LDL cholesterol, HDL cholesterol, hs-CRP, age, BMI, and smoking status.

Conclusions:

  • In healthy adults, plasma KIM-1 is not associated with renal function.
  • Plasma KIM-1 is independently related to multiple cardiovascular risk factors in the general population.
Abstract

Keywords:
Blood pressureCardiovascular risk factorsEstimated glomerular filtration rateKidney injury molecule-1Renal function

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