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Fast and non-destructive pore structure analysis using terahertz time-domain spectroscopy.

Daniel Markl1, Prince Bawuah2, Cathy Ridgway3

  • 1Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, CB3 0AS Cambridge, UK.

International Journal of Pharmaceutics
|December 17, 2017
PubMed
Summary

A new parameter, Sa, quantifies pore structure anisotropy in pharmaceutical tablets using terahertz spectroscopy. Material properties like granule density significantly impact tablet microstructure and performance.

Keywords:
AnisotropyDisintegrationMicrostructurePharmaceutical tabletPore structureTerahertz

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Physical Chemistry

Background:

  • Pharmaceutical tablet manufacturing via uni-axial compaction results in anisotropic mechanical and pore structures.
  • Understanding tablet microstructure is crucial for predicting drug performance, particularly liquid imbibition during disintegration.

Purpose of the Study:

  • To introduce a novel quantitative parameter, Sa, for characterizing pore structure anisotropy in pharmaceutical tablets.
  • To investigate the influence of material attributes and compaction on tablet pore anisotropy.

Main Methods:

  • Terahertz time-domain spectroscopy was employed to measure pore structure anisotropy.
  • The Sa parameter was applied to diverse tablet formulations, including single excipient, drug-excipient mixtures, and complex granulated products.

Main Results:

  • Significant structural anisotropies were observed in all investigated tablets.
  • Overall porosity, tablet thickness, particle size distribution, and granule density were identified as key factors influencing anisotropy.
  • The Sa parameter demonstrated effectiveness in analyzing multi-component formulations.

Conclusions:

  • The Sa parameter offers valuable insights into tablet microstructure and anisotropy.
  • Material attributes, such as granule density, directly impact pore structure and subsequent tablet performance (e.g., liquid imbibition).
  • Further understanding of the interplay between material properties, compaction, and microstructure is essential for optimizing tablet design.