Related Experiment Video
Updated: Feb 16, 2026

An Aptamer-based Sensor for Unchelated GadoliniumIII
Published on: January 9, 2017
Insight into the dynamic of gadolinium based contrast agent (GBCA) hypersensitivity: Acquisition, persistence and
Ingrid Boehm1, Martin Hungerbühler1, Johannes T Heverhagen1
1Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Switzerland; Experimental Radiology, Department of BioMedical Research, University of Bern, Switzerland.
Abstract:
Anaphylaxis against gadolinium based contrast agents (GBCAs) has been reported in all severity grades but is less frequent than hypersensitivity/allergy against iodinated contrast materials. Once a patient acquires such an adverse reaction a life-long premedication is usually the consequence in concert with GBCA-enhanced MR-imaging procedures. The usefulness of this prophylaxis has been questioned, and discussed controversially during the past. The herein presented case may shed some light into the dynamic of contrast-medium-induced hypersensitivity reactions.
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