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Racemization of aspartyl residues in proteins from normal and cataractous human lenses: an aging process without
P J van den Oetelaar1, H J Hoenders
1Department of Biochemistry, University of Nijmegen, The Netherlands.
Experimental Eye Research
|February 1, 1989
Abstract:
A highly sensitive method was used to determine D- and L-aspartyl residues in protein fractions from normal and cataractous human lenses. A linear relationship with age was found in all fractions from normal lenses. However, no correlation with cataract could be established. It is concluded that racemization of aspartyl residues is a continuous process in eye-lens proteins but plays no role in cataract formation.