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Updated: Feb 16, 2026

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Intestinal permeability and Ménière's disease.

F Di Berardino1, D Zanetti1, E Ciusani2

  • 1Audiology Unit, Head and Neck Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Department of Clinical Sciences and Community Health, University of Milan, Italy.

American Journal of Otolaryngology
|December 18, 2017
PubMed
Summary
This summary is machine-generated.

Symptomatic Ménière disease (MD) patients show increased intestinal permeability, indicated by elevated lactulose and mannitol absorption and fecal calprotectin (FC) levels. These markers may aid in MD diagnosis.

Keywords:
Double sugar testFecal calprotectinIntestinal permeabilityLactuloseMannitolMénière

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Area of Science:

  • Gastroenterology
  • Otolaryngology
  • Immunology

Background:

  • Ménière disease (MD) is a chronic condition causing vertigo, hearing loss, and ear fullness.
  • Patients with MD often experience gastrointestinal issues linked to autonomic dysfunction.
  • Dietary changes have shown potential benefits for MD symptoms.

Purpose of the Study:

  • To investigate intestinal permeability in Ménière disease patients.
  • To assess urinary lactulose and mannitol levels and fecal calprotectin (FC) in active and inactive MD.
  • To explore the relationship between MD and gut health.

Main Methods:

  • Studied 26 patients with definite unilateral MD: 14 symptomatic and 12 asymptomatic.
  • Included 20 healthy volunteers as a control group.
  • Administered a double sugar test (lactulose and mannitol) and fecal calprotectin (FC) assay.

Main Results:

  • Symptomatic MD patients exhibited significantly higher lactulose and mannitol absorption compared to asymptomatic patients and controls.
  • Fecal calprotectin (FC) levels were elevated exclusively in the symptomatic MD group.
  • These findings suggest increased intestinal permeability in active MD.

Conclusions:

  • Altered intestinal permeability was detected solely in symptomatic MD patients.
  • A potential link between MD and intestinal permeability is proposed.
  • The double-sugar test and FC quantification could be valuable additions to MD diagnostic criteria.