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New therapies for atopic dermatitis: Additional treatment classes.
Paras P Vakharia1, Jonathan I Silverberg2
1Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Journal of the American Academy of Dermatology
|December 18, 2017
Summary
New miscellaneous agents are being studied for atopic dermatitis (AD) treatment. While many show therapeutic promise, more research is needed to confirm their efficacy and safety for managing this chronic skin condition.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Atopic dermatitis (AD) management is evolving with novel therapeutic agents.
- A diverse range of miscellaneous agents are under investigation for AD treatment.
Purpose of the Study:
- To review the efficacy and safety of novel agents for atopic dermatitis.
- To analyze agents by their mechanism of action in AD treatment.
Main Methods:
- A nonsystematic literature review was conducted.
- Searches of PubMed and ClinicalTrials.gov identified studies on new AD agents.
- Included randomized controlled trials and other relevant study types.
Main Results:
- Evaluated agents include omiganan, tapinarof, PR022, asimadoline, DS107, ZPL-389, secukinumab, and fezakinumab.
- Data on efficacy and safety were analyzed based on each agent's mechanism of action.
- Limited clinical data are available for many agents.
Conclusions:
- Advancements in understanding AD pathogenesis have led to diverse novel agents.
- Many new agents demonstrate significant therapeutic potential for atopic dermatitis.
- Continued research and development are essential for these promising AD treatments.
Keywords:
asimadolineatopic dermatitisemerging agentsfezakinumabhypocholrous acidomiganansecukinumabtapinarofMore Related Videos
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