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Updated: Feb 16, 2026

The CryoAPEX Method for Electron Microscopy Analysis of Membrane Protein Localization Within Ultrastructurally-Preserved Cells
Published on: February 27, 2020
Elusively reaching the apex
Luke Halliday1, Paul Ikgan Sia1, Dinesh Selva1
1Department of Ophthalmology & Visual Sciences, University of Adelaide, South Australia, Australia; South Australian Institute of Ophthalmology, Royal Adelaide Hospital, South Australia, Australia.
Abstract:
A 64-year-old man presented with a 3-month history of diplopia and left-sided proptosis. Examination was significant for impairment of his left second, third, fourth, fifth, sixth, and seventh cranial nerves. Magnetic resonance imaging revealed a left orbital apex and cavernous sinus lesion. However, subtle thickening of his left frontal and supraorbital nerve was not identified until later. A trial of steroids provided minimal effect. Biopsy of the lesion showed a well-differentiated squamous cell carcinoma. The patient was subsequently managed with palliative radiotherapy.
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